Biomolecular Core publications

Annalucia Darbey,Diane Rebourcet et al. “A comparison of in vivo viral targeting systems identifies adeno-associated virus serotype 9 (AAV9) as an effective vector for genetic manipulation of Leydig cells in adult mice.” Andrology 2021; 460-473

Loiuse Saul, Iris Mair et al. “1,25Dihydroxyvitamin D3 restrains CD4+ T cell priming ability of CD11c+ dendritic cells by upregulating expression of CD31.” Front. Immunol. 2019; 10

Peter O’Shaughnessy, Rod Mitchell et al. “Androgen receptor expression is required to ensure devlelpoment of adult Leydig cells and to prevent deve;opemnt of steroidogenic cells with adrenal characteristics in the mouse testes.” BMC Develop. Biol. 2019; 19:8

Joni Macdonald, Karen R. Kilcoyne, et al. “DMRT1 repression using a novel approach to genetic manipulation induces testicular dysgenesis in human fetal gonads.Hum. Reprod. Sept 2018.

Makieva S, Hutchinson LJ, et al. “Androgen-induced relaxation of uterine myocytes is mediated by blockade of both Ca2+ flux and MLC phosphorylation.J. Clin. Endocrinol. Metab. 2016.

Bar-Lev TH, Harris D, et al. “Role of PI4K and PI3K-AKT in ERK 1/2 activation by GnRH in the pituitary gonadotropes.Mol. Cell. Endocrinol. 2015; 415: 12-23.

Eddie SL, Childs AJ, et al. “Prokineticin ligands and receptors are expressed in the human fetal ovary and regulate germ cell expression of COX2.J. Clin. Endocrinol. Metab. 2015; 100(9): E1197-E1205.

Willems A, Roesl C, Mitchell RT, et al. “Sertoli cell androgen receptor signalling in adulthood is essential for post-meiotic germ cell development.” Mol. Reprod. Dev. 2015; 82 (9): 626-627.

McCloskey C, Rada C, et al. “The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.” EMBO Mol. Med. 2014; 6(9): 1161-1174.

Orr B, Grace CO, Brown P, et al. “Reduction of pro-tumourigenic activity of prostate cancer associated fibroblasts using Dlk1 or SCUBE1.” Disease Mod. and Mech. 2013; 6(2): 530-6.

Smith LB, Milne L, Nelson N, et al. “KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.” PLoS Genet.. 2012;8(5):e1002697.

Macdonald LJ, Sales KJ, Grant V, Brown P, Jabbour HN, Catalano RD. “Prokineticin 1 induces Dickkopf 1 expression and regulates cell proliferation and decidualization in the human endometrium.” Mol. Hum. Reprod. 2011; 17(10): 626-36.

Maybin JA, Hirani N, Brown P, Jabbour HN, Critchley HOD. “The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair.” J. Clin. Endocrinol. Metab.. 2011; 96(8): 2475-83.

Bombail V, Collins F, Brown P, Saunders PTK. “Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.” Mol. Cell. Endocrinol. 2010;314(1):53-61.

Keightley MC, Brown P, Jabbour HN, Sales KJ. “F-Prostaglandin receptor regulates endothelial cell function via fibroblast growth factor-2.” BMC Cell Biol.. 2010;11:8.

Maldonado-Pérez D, Brown P, Morgan K, Millar RP, Thompson AE, Jabbour HN. “Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway.” Biochim. Biophys. Acta. 2009;1793(7):1315-24.

Evans J, Catalano RD, Brown P, et al. “Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor.” FASEB J.. 2009;23(7):2165-75.

Hooley RP, Paterson M, Brown P, Kerr K, Saunders PTK. “Intra-testicular injection of adenoviral constructs results in Sertoli cell-specific gene expression and disruption of the seminiferous epithelium.” Reproduction. 2009;137(2):361-70.

Sales KJ, Maldonado-Pérez D, Grant V, et al. “Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.” Biochim. Biophys. Acta. 2009;1793(12):1917-28.

Collins F, MacPherson S, Brown P, et al. “Expression of oestrogen receptors, ERalpha, ERbeta, and ERbeta variants, in endometrial cancers and evidence that prostaglandin F may play a role in regulating expression of ERalpha.” BMC Cancer. 2009;9:330.

Bessos H, Matviyenko M, Brown P, et al. “What’s happening–probing of HPA-1a antigen-antibody interaction by surface plasmon resonance technology.” Transfus. Apher. Sci.. 2008;39(2):179-82.

Maudsley S, Naor Z, Bonfil D, et al. “Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene.” Mol. Endocrinol.. 2007;21(5):1216-33.

Naor Z, Jabbour HN, Naidich M, et al. “Reciprocal cross talk between gonadotropin-releasing hormone (GnRH) and prostaglandin receptors regulates GnRH receptor expression and differential gonadotropin secretion.” Mol. Endocrinol.. 2007;21(2):524-37.

López de Maturana R, Martin B, Millar RP, et al. “GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.” Neuromolecular Med.. 2007;9(3):230-48.

Larder R, Karali D, Nelson N, Brown P. “Fanconi anemia A is a nucleocytoplasmic shuttling molecule required for gonadotropin-releasing hormone (GnRH) transduction of the GnRH receptor.” Endocrinology. 2006;147(12):5676-89.

Larder R, Chang L, Clinton M, Brown P. “Gonadotropin-releasing hormone regulates expression of the DNA damage repair gene, Fanconi anemia A, in pituitary gonadotroph cells.” Biol. Reprod.. 2004;71(3):828-36.

Brown P, Scobie GA, Townsend J, et al. “Identification of a novel missense mutation that is as damaging to DAX-1 repressor function as a nonsense mutation.” J. Clin. Endocrinol. Metab.. 2003;88(3):1341-9.

Quirk J, Brown P. “Hesx1 homeodomain protein represses transcription as a monomer and antagonises transactivation of specific sites as a homodimer.” J. Mol. Endocrinol.. 2002;28(3):193-205.